無力症(バセットハウンド系)

無力症(バセットハウンド系)

¥16,600
  • TEST OVERVIEW:
    罹患犬は血小板の機能に異常があります。血小板とは、血液を正常に凝固させる役割を持つ血液細胞のことです。この血小板の「異常」により、血小板同士がうまくくっつかなくなり、正常に血液を固めることができなくなります。過剰出血や自然出血のリスクは、軽度から重度まで様々です。最も一般的な症状は、鼻血の再発と、歯を抜いたときや硬いものを噛んだときに起こる歯ぐきの過度の出血です。また、アザができやすく、皮膚の下に血の塊(血腫)ができることがあり、特に耳の先端に多く見られます。
  • カテゴリー:
    血液・リンパ性疾患 - 血液とリンパに関連する疾患
  • static-content..gene:
    RASGRP1
  • Variant Detected:
    c.del512-514TCT p.171Fdel
  • Severity:
    Moderate. This disease can cause significant signs of discomfort and/or dysfunction in affected animals. It may involve relatively high treatment/management costs, and can sometimes reduce life expectancy.
  • MODE OF INHERITANCE:
    Autosomal Recessive
  • RESEARCH CITATION(S):
    2008 Boudreaux, MK. : Characteristics, diagnosis, and treatment of inherited platelet disorders in mammals. J Am Vet Med Assoc 233:1251-9, 1190, 2008. Pubmed reference: 18922051. DOI: 10.2460/javma.233.8.1251. 2007 Boudreaux, MK., Catalfamo, JL., Klok, M. : Calcium-diacylglycerol guanine nucleotide exchange factor I gene mutations associated with loss of function in canine platelets. Transl Res 150:81-92, 2007. Pubmed reference: 17656327. DOI: 10.1016/j.trsl.2007.03.006. 1995 Callan, M.B., Bennett, J.S., Phillips, D.K., Haskins, M.E., Hayden, J.E., Anderson, J.G., Giger, U. : Inherited platelet delta-storage pool disease in dogs causing severe bleeding - an animal model for a specific adp deficiency Thrombosis & Haemostasis 74:949-953, 1995. 1994 Boudreaux, M.K., Crager, C., Dillon, A.R., Stanz, K., Toiviokinnucan, M. : Identification of an Intrinsic Platelet Function Defect in Spitz Dogs Journal of Veterinary Internal Medicine 8:93-98, 1994. Pubmed reference: 8046682. 1993 Brooks, M., Catalfamo, J. : Buccal Mucosa Bleeding Time Is Prolonged in Canine Models of Primary Hemostatic Disorders Thrombosis and Haemostasis 70:777-780, 1993. Pubmed reference: 8128434. 1989 Patterson, W.R., Estry, D.W., Schwartz, K.A., Borchert, R.D., Bell, T.G. : Absent Platelet Aggregation with Normal Fibrinogen Binding in Basset Hound Hereditary Thrombopathy Thrombosis and Haemostasis 62:1011-1015, 1989. Pubmed reference: 2512673. 1988 Catalfamo, JL., Dodds, WJ. : Hereditary canine thrombopathia. Vet Clin North Am Small Anim Pract 18:273-4, 1988. Pubmed reference: 3258696. 1986 Catalfamo, JL., Raymond, SL., White, JG., Dodds, WJ. : Defective platelet-fibrinogen interaction in hereditary canine thrombopathia. Blood 67:1568-77, 1986. Pubmed reference: 3011147. 1985 Patterson, W.R., Padgett, G.A., Bell, T.G. : Abnormal release of storage pool adenine nucleotides from platelets of dogs affected with basset hound hereditary thrombopathy. Thromb Res 37:61-71, 1985. Pubmed reference: 3983903. 1979 Johnstone, IB., Lotz, F. : An inherited platelet function defect in Basset hounds. Can Vet J 20:211-5, 1979. Pubmed reference: 509382

無力症(バセットハウンド系)

¥16,600

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