Myxomatous Mitral Valve Disease (MVD Risk Variants)

Myxomatous Mitral Valve Disease (MVD Risk Variants)

¥16,600
  • TEST OVERVIEW:
    Myxomatous mitral valve disease (MMVD) is also known as mitral regurgitation, degenerative mitral valve disease and endocardiosis. Myxomatous Mitral Valve Disease, often referred to as simply Mitral Valve Disease (MVD), is a common heart condition in dogs, particularly in small to medium-sized breeds and some toy breeds. Research into the genetics of MMVD in dogs has revealed that genetic factors can influence the severity and progression of the disease. While I don't have information on specific NEBL variants, I can explain that studies have identified certain genes and genetic markers associated with an increased risk of developing MMVD, as well as the rate of disease progression.
  • カテゴリー:
    心血管疾患 - 心臓と血管に関連する疾患
  • static-content..gene:
    NEBL (linkage marker)
  • Variant Detected:
    Base Substitution c.1151A>C p.Gln384Pro
  • Severity:
    Moderate. This disease can cause significant signs of discomfort and/or dysfunction in affected animals. It may involve relatively high treatment/management costs, and can sometimes reduce life expectancy.
  • MODE OF INHERITANCE:
    Autosomal Recessive with Incomplete Penetrance
  • RESEARCH CITATION(S):
    https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1009726 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7602727/ https://onlinelibrary.wiley.com/doi/full/10.1111/age.13082

Myxomatous Mitral Valve Disease (MVD Risk Variants)

¥16,600

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