Autoimmune Lymphoproliferative Syndrome

Autoimmune Lymphoproliferative Syndrome

¥16,600
  • TEST OVERVIEW:
    This disease is characterised by a build up of immune cells on the spleen and lymph nodes. Symptoms tend to be seen at around 6 to 8 weeks and progression tends to be quite rapid after that. Affected kittens show abdominal distension, tend to be lethargic and show weight loss due to anaemia.
  • カテゴリー:
    免疫疾患 - 免疫系の臓器や細胞に関連する疾患
  • static-content..gene:
    FASL
  • Variant Detected:
    c.413-414InsA
  • Severity:
    Moderate-Severe. This is a disease with significant welfare impact on the affected animal, in terms of clinical signs and generally reduced life expectancy.
  • MODE OF INHERITANCE:
    Autosomal Recessive
  • RESEARCH CITATION(S):
    1Aberdein D, Munday JS, Gandolfi B, Dittmer KE, Malik R, Garrick DJ, Lyons LA & 99 Lives Consortium (2017). A FAS-ligand variant associated with autoimmune lymphoproliferative syndrome in cats. Mammalian Genome 28, 47- 55. Aberdein D, Munday JS, Fairly RA, Vernau W & Thompson KG (2015). A novel and likely inherited lymphoproliferative disease in British Shorthair kittens. Veterinary Pathology 52, 1176-1182.

Autoimmune Lymphoproliferative Syndrome

¥16,600

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